Postdoctoral position, laboratory of Thomas Preat (ESPCI/CNRS, Paris, France)

Postdoctoral position, laboratory of Thomas Preat (ESPCI/CNRS, Paris, France)

Memory and brain energy metabolism.

Our lab advertises postdoctoral positions to investigate brain energy metabolism in Drosophila, in link with memory formation. The lab is located at ESPCI, in the center of Paris, and benefits from an international and multidisciplinary environment, both within ESPCI and via other research institutes in the neighborhood. In addition to the PI, the lab hosts 3 senior scientists with permanent positions and several technicians. Our team is among the world leaders in the study of Drosophila learning and memory, combining high-throughput behavioral assays and 2-photon or confocal in vivo imaging. We made several pioneer discoveries in this field, concerning the molecular pathways and the neuronal circuits involved in the different forms of olfactory memories (see the selection of recent publications below). Our investigations on the mechanisms of memory consolidation recently pushed us towards the understudied field of brain energy metabolism in the fly. Using innovative tools to monitor neuronal energy flux in vivo at the cellular resolution, we recently showed that metabolic plasticity in the mushroom bodies, the fly’s learning and memory neuronal center, determines the persistence of memory following an associative learning. Our project, supported by an ERC Advanced Grant, is to study the neuronal circuits and molecular signaling involved in the regulation of brain energy metabolism, and its coupling with glial cells. Of special interest to us is to link functional imaging data with behavioral experiments to investigate in vivo the dynamics of energy metabolism in the context of longterm memory formation. We have several opportunities for postdoctoral positions on this broad and exciting research theme. An experience in Drosophila neurobiology, in fluorescence imaging, or in brain energy metabolism will be considered positively.

The major selection criteria are a strong motivation for the project, and a proven ability to conduct high-quality research. A good command of English is required. The salary will be funded by our ERC grant for a minimum of 2 years. The salary will be of 2500€/month, and it will be adjusted according to the CNRS scale on the basis of the past experience as a postdoctoral fellow. The starting date is flexible in 2019.

Interested scientists should send a motivation letter, a CV and contact information for at least 2 referees to Thomas Preat: thomas.preat@espci.fr Preselected applicants will be interviewed and will be invited to present their achievements during a seminar. For more information on the team, please visit http://www.gdsm.espci.fr

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Dr. Lu

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